abstract：:Scrub typhus, caused by Orientia tsutsugamushi, has recently emerged in northern China where the disease had not been known to exist. Although doxycycline and azithromycin are the recommended agents for the treatment of scrub typhus, clinical responses depend both on the susceptibilities of various O. tsutsugamushi st...

journal_title：International journal of antimicrobial agents

authors： Zhao M,Wang T,Yuan X,Du W,Lin M,Shen Y

更新日期：2016-09-01 00:00:00

abstract：:Clostridium difficile infection (CDI) is the leading cause of infectious healthcare-associated diarrhoea. Recurrent CDI increases disease morbidity and mortality, posing a high burden to patients and a growing economic burden to the healthcare system. Thus, there exists a significant unmet and increasing medical need ...

journal_title：International journal of antimicrobial agents

authors： Vickers RJ,Tillotson G,Goldstein EJ,Citron DM,Garey KW,Wilcox MH

更新日期：2016-08-01 00:00:00

abstract：:The fungal pathogen Cryptococcus neoformans poses a major threat to immunocompromised patients and is a leading killer of human immunodeficiency virus (HIV)-infected patients worldwide. Cryptococci are known to manipulate host macrophages and can either remain latent or proliferate intracellularly within the host phag...

journal_title：International journal of antimicrobial agents

authors： Samantaray S,Correia JN,Garelnabi M,Voelz K,May RC,Hall RA

更新日期：2016-07-01 00:00:00

abstract：:Eighteen hot topics regarding the diagnosis and management of skin and soft-tissue infections (SSTIs) were selected and reviewed by members of the SSTI Working Group of the International Society of Chemotherapy (ISC). Despite the large amount of literature available on the issue selected, there are still many unknowns...

journal_title：International journal of antimicrobial agents

authors： Esposito S,Bassetti M,Bonnet E,Bouza E,Chan M,De Simone G,Dryden M,Gould I,Lye DC,Saeed K,Segreti J,Unal S,Yalcin AN,International Society of Chemotherapy (ISC).

更新日期：2016-07-01 00:00:00

abstract：:The use of antibiotics, as any other drug, is regulated by the terms of its marketing authorisation, notified in the Summary of Product Characteristics (SPC). If a prescription is not in accordance with the SPC, the physician prescribes off-label. There is very little literature regarding off-label use of antibiotics ...

journal_title：International journal of antimicrobial agents

authors： Davido B,Bouchand F,Calin R,Makhloufi S,Lagrange A,Senard O,Perronne C,Villart M,Salomon J,Dinh A

更新日期：2016-06-01 00:00:00

abstract：:The objective of this study was to comprehensively identify the target genes regulated by the two-component regulatory system VraSR in Staphylococcus aureus and to clarify the role of VraSR in low-level vancomycin resistance. Expression of vraS was determined by real-time quantitative reverse transcriptase PCR (qRT-PC...

journal_title：International journal of antimicrobial agents

authors： Chen H,Xiong Z,Liu K,Li S,Wang R,Wang X,Zhang Y,Wang H

更新日期：2016-05-01 00:00:00

abstract：:In this study, 27 clinical isolates of Candida glabrata with voriconazole (VRC) minimum inhibitory concentrations (MICs) ranging from ≤0.03 μg/mL to 8 μg/mL were tested to determine whether in vitro data are predictive of in vivo efficacy. The efficacy of VRC administered at 40 mg/kg was assayed in a neutropenic murin...

journal_title：International journal of antimicrobial agents

authors： Sanchis M,Capilla J,Castanheira M,Martin-Vicente A,Sutton DA,Fothergill AW,Wiederhold NP,Guarro J

更新日期：2016-04-01 00:00:00

abstract：:The aim of this review was to evaluate the susceptibility of contemporary Gram-positive and Gram-negative bacteria to fosfomycin. PubMed and Scopus databases were systematically searched to identify studies published in print or electronically from January 2010 until June 2015. In total, 84 studies were selected. Susc...

journal_title：International journal of antimicrobial agents

authors： Vardakas KZ,Legakis NJ,Triarides N,Falagas ME

更新日期：2016-04-01 00:00:00

abstract：:Carbapenemase-producing Klebsiella pneumoniae (CP-Kp) are currently among the most important nosocomial pathogens in many geographic regions. A retrospective study was conducted between 2010 and 2014 in four hospitals located in a high-prevalence area (Athens, Greece) to describe the clinical features, treatment and o...

journal_title：International journal of antimicrobial agents

authors： Tofas P,Skiada A,Angelopoulou M,Sipsas N,Pavlopoulou I,Tsaousi S,Pagoni M,Kotsopoulou M,Perlorentzou S,Antoniadou A,Pirounaki M,Skoutelis A,Daikos GL

更新日期：2016-04-01 00:00:00

abstract：:The objective of this study was to examine the in vitro synergism of three-drug combinations against Mycobacterium tuberculosis (levofloxacin/linezolid/ethambutol, levofloxacin/amikacin/ethambutol and levofloxacin/linezolid/amikacin) using the time-kill curves method. In total, 8 multidrug-resistant and 12 drug-suscep...

journal_title：International journal of antimicrobial agents

authors： López-Gavín A,Tudó G,Rey-Jurado E,Vergara A,Hurtado JC,Gonzalez-Martín J

更新日期：2016-01-01 00:00:00

abstract：:Treatment options for multidrug-resistant (MDR) strains of Acinetobacter baumannii that acquire resistance to colistin are limited. Acinetobacter baumannii can become highly resistant to colistin through complete loss of lipopolysaccharide (LPS) owing to mutations in the genes encoding the first three enzymes involved...

journal_title：International journal of antimicrobial agents

authors： García-Quintanilla M,Carretero-Ledesma M,Moreno-Martínez P,Martín-Peña R,Pachón J,McConnell MJ

更新日期：2015-12-01 00:00:00

abstract：:Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most promising biomarker is solub...

journal_title：International journal of antimicrobial agents

authors： Eugen-Olsen J,Giamarellos-Bourboulis EJ

更新日期：2015-12-01 00:00:00

abstract：:Infectious diseases are among the most common reasons for admission to hospital and can easily lead to sepsis. Sepsis is globally associated with increased mortality, and although biomarkers could help clinicians in the early diagnosis of sepsis and immediate onset of antibiotics, there are always questions to be answ...

journal_title：International journal of antimicrobial agents

authors： Tziolos N,Kotanidou A,Orfanos SE

更新日期：2015-12-01 00:00:00

abstract：:The Candida albicans zinc cluster proteins are a family of transcription factors (TFs) that play essential roles in the development of antifungal drug resistance. Gain-of-function mutations in several TFs, such as Tac1p, Mrr1p and Upc2p, have been previously well documented in azole-resistant clinical C. albicans isol...

journal_title：International journal of antimicrobial agents

authors： Wang Y,Liu JY,Shi C,Li WJ,Zhao Y,Yan L,Xiang MJ

更新日期：2015-11-01 00:00:00

abstract：:The epidemiology of multidrug-resistant bacteria (MDRB) has changed significantly in European healthcare settings, with a decrease in frequency of meticillin-resistant Staphylococcus aureus and an increase in extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. Little is known about the effects of these ...

journal_title：International journal of antimicrobial agents

authors： Fihman V,Messika J,Hajage D,Tournier V,Gaudry S,Magdoud F,Barnaud G,Billard-Pomares T,Branger C,Dreyfuss D,Ricard JD

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:Paper-based interventions have been shown to stimulate switching from intravenous (i.v.) to oral (p.o.) antibiotic therapies. Shorter i.v. durations are associated with a lower risk of iatrogenic infections as well as reduced workload and costs. The purpose of this study was to determine whether automated el...

journal_title：International journal of antimicrobial agents

authors： Beeler PE,Kuster SP,Eschmann E,Weber R,Blaser J

更新日期：2015-10-01 00:00:00

abstract：:Vancomycin is a glycopeptide antibiotic widely used in the management of meticillin-resistant Staphylococcus aureus (MRSA). Guidelines currently recommend vancomycin be administered by intermittent infusion, despite recent research suggesting that continuous infusion (CI) may be associated with lower rates of vancomyc...

journal_title：International journal of antimicrobial agents

authors： Hanrahan T,Whitehouse T,Lipman J,Roberts JA

更新日期：2015-09-01 00:00:00

abstract：:The emergence of glycopeptide reduced susceptibility and resistance in Staphylococcus aureus strains is a growing clinical problem that poses significant clinical challenges in treatment. Its development is a complex and novel process involving many subtle physiological changes in the micro-organism. Daptomycin is the...

journal_title：International journal of antimicrobial agents

authors： Stefani S,Campanile F,Santagati M,Mezzatesta ML,Cafiso V,Pacini G

更新日期：2015-09-01 00:00:00

abstract：:Since its introduction in the 1950s, colistin has been used mainly as a topical treatment in human medicine owing to its toxicity when given systemically. Sixty years later, colistin is being used as a last-resort drug to treat infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter bauman...

journal_title：International journal of antimicrobial agents

authors： Catry B,Cavaleri M,Baptiste K,Grave K,Grein K,Holm A,Jukes H,Liebana E,Lopez Navas A,Mackay D,Magiorakos AP,Moreno Romo MA,Moulin G,Muñoz Madero C,Matias Ferreira Pomba MC,Powell M,Pyörälä S,Rantala M,Ružauskas M,Sa

更新日期：2015-09-01 00:00:00

abstract：:Resistance among mycobacteria leading to multidrug-resistant and extensively drug-resistant tuberculosis is a major threat. However, nanotechnology has provided new insights in drug delivery and medicine development. This is the first comparative report to determine the activity of chemically and biologically synthesi...

journal_title：International journal of antimicrobial agents

authors： Singh R,Nawale LU,Arkile M,Shedbalkar UU,Wadhwani SA,Sarkar D,Chopade BA

更新日期：2015-08-01 00:00:00

abstract：:The activity of eight aminoglycosides (amikacin, apramycin, arbekacin, gentamicin, kanamycin, neomycin, netilmicin and tobramycin) against a collection of 257 amoxicillin/clavulanic acid (AMC)-resistant Escherichia coli isolates was determined by microdilution. Aminoglycoside resistance rates, the prevalence of aminog...

journal_title：International journal of antimicrobial agents

authors： Fernández-Martínez M,Miró E,Ortega A,Bou G,González-López JJ,Oliver A,Pascual A,Cercenado E,Oteo J,Martínez-Martínez L,Navarro F,Spanish Network for the Research in Infectious Diseases (REIPI).

更新日期：2015-08-01 00:00:00

abstract：:This study aimed to forecast the incidence rate of carbapenem resistance and to assess the impact of an antimicrobial stewardship intervention using routine antimicrobial consumption surveillance data. Following an outbreak of OXA-48-producing Klebsiella pneumoniae (January 2008-April 2010) in a renal cohort in London...

journal_title：International journal of antimicrobial agents

authors： Gharbi M,Moore LS,Gilchrist M,Thomas CP,Bamford K,Brannigan ET,Holmes AH

更新日期：2015-08-01 00:00:00

abstract：:In this study, 619 individual Escherichia coli isolates from food-producing and companion animals were analysed to determine the prevalence of the cephalosporinase gene blaCMY-2. In total, 18 CMY-2-producers (2.9%) were detected and exhibited multidrug-resistant phenotypes. One of the CMY-2-producers was found to poss...

journal_title：International journal of antimicrobial agents

authors： Fang LX,Sun J,Li L,Deng H,Huang T,Yang QE,Li X,Chen MY,Liao XP,Liu YH

更新日期：2015-08-01 00:00:00

abstract：:Here we describe a patient undergoing extensive abdominal surgery and hyperthermic intraperitoneal chemotherapy due to primary adenocarcinoma in the sigmoid colon with peritoneal carcinomatosis. During hospitalisation the patient suffered from bacteraemia with a multidrug-resistant Bacteroides fragilis isolate. Whole-...

journal_title：International journal of antimicrobial agents

authors： Ank N,Sydenham TV,Iversen LH,Justesen US,Wang M

更新日期：2015-07-01 00:00:00

abstract：:Gene modifications in the PmrAB and PhoPQ two-component regulatory systems, as well as inactivation of the mgrB gene, are known to be causes of colistin resistance in Klebsiella pneumoniae. The objective of this study was to characterise the mechanism involved in colistin resistance in a Klebsiella oxytoca isolate. A ...

journal_title：International journal of antimicrobial agents

authors： Jayol A,Poirel L,Villegas MV,Nordmann P

更新日期：2015-07-01 00:00:00

abstract：:Influenza is a heavy socially significant viral infection that affects humans, birds, and wild and domestic animals. The threat of existing and new highly pathogenic subtypes of influenza A virus (IAV) makes it necessary to develop an effective drug that may affect different IAV strains. For this purpose, oligodeoxynu...

journal_title：International journal of antimicrobial agents

authors： Levina AS,Repkova MN,Mazurkova NA,Makarevich EV,Ismagilov ZR,Zarytova VF

更新日期：2015-07-01 00:00:00

abstract：:Prolonged infusion (PI) of β-lactam antibiotics is increasingly used in order to optimise antibiotic exposure in critically ill patients. Physicians are often not aware of a number of subtleties that may jeopardise the treatment. In this clinically based paper, we stress pragmatic issues, such as the importance of a l...

journal_title：International journal of antimicrobial agents

authors： De Waele JJ,Lipman J,Carlier M,Roberts JA

更新日期：2015-05-01 00:00:00

abstract：:The objective of this study was to better understand the in vitro activity of flomoxef against clinical extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. A total of 401 ESBL-producing isolates, including 196 Escherichia coli, 124 Klebsiella pneumoniae and 81 Proteus mirabilis, were collected consecuti...

journal_title：International journal of antimicrobial agents

authors： Yang Q,Zhang H,Cheng J,Xu Z,Xu Y,Cao B,Kong H,Ni Y,Yu Y,Sun Z,Hu B,Huang W,Wang Y,Wu A,Feng X,Liao K,Shen D,Hu Z,Chu Y,Lu J,Su J,Gui B,Duan Q,Zhang S,Shao H

更新日期：2015-05-01 00:00:00

abstract：:As a follow-up to our 2009 survey, in order to explore opinion and practice on the epidemiology and management of meticillin-resistant Staphylococcus aureus (MRSA) in Europe, we conducted a second survey to elicit current opinions on this topic, particularly around antibiotic choice, dose, duration and route of admini...

journal_title：International journal of antimicrobial agents

authors： Dryden M,Andrasevic AT,Bassetti M,Bouza E,Chastre J,Baguneid M,Esposito S,Giamarellou H,Gyssens I,Nathwani D,Unal S,Voss A,Wilcox M

更新日期：2015-04-24 00:00:00

abstract：:There is strong evidence that self-monitoring and feedback are effective behaviour change techniques (BCTs) across a range of healthcare interventions and that their effectiveness is enhanced by goal setting and action planning. Here we report a summary of the update of a systematic review assessing the application of...

journal_title：International journal of antimicrobial agents

authors： Davey P,Peden C,Charani E,Marwick C,Michie S

更新日期：2015-03-01 00:00:00

abstract：:The aim of this study was to determine the clinical characteristics, molecular epidemiology and biofilm production of Acinetobacter baumannii clinical isolates obtained from a tertiary-care hospital in Mexico. Clinical isolates of A. baumannii (n=152) isolated from 2007 to 2012 were included. Clonal diversity was anal...

journal_title：International journal of antimicrobial agents

authors： Bocanegra-Ibarias P,Peña-López C,Camacho-Ortiz A,Llaca-Díaz J,Silva-Sánchez J,Barrios H,Garza-Ramos U,Rodríguez-Flores AM,Garza-González E

更新日期：2015-03-01 00:00:00

abstract：:We sought to evaluate published evidence regarding clinical or microbiological outcomes related to the use of inhaled antibiotics other than aminoglycosides, polymyxins and aztreonam. A systematic search of PubMed and Scopus databases as well as bibliographies of eligible articles was performed. In total, 34 eligible ...

journal_title：International journal of antimicrobial agents

authors： Falagas ME,Trigkidis KK,Vardakas KZ

更新日期：2015-03-01 00:00:00

abstract：:Acinetobacter baumannii has emerged as an important nosocomial pathogen owing to its increasing resistance to most, if not all, antibiotics in clinical use. We recently reported the occurrence of extensively drug-resistant (XDR) A. baumannii isolates in a Malaysian tertiary hospital. The genome of one of these XDR iso...

journal_title：International journal of antimicrobial agents

authors： Lean SS,Yeo CC,Suhaili Z,Thong KL

更新日期：2015-02-01 00:00:00

abstract：:The objective of this study was to investigate the drug resistance characteristics of Mycobacterium tuberculosis isolates to four first-line antituberculous drugs (ATDs) from tuberculosis (TB) patients with AIDS in Beijing, China. All M. tuberculosis strains were isolated from specimens from TB patients with AIDS hosp...

journal_title：International journal of antimicrobial agents

authors： Gao GJ,Lian L,Sun Y,Wei J,Xiao J,Wang X,Zhang L,Zhao X,Yang D,Zhao HX,Zhao H,Wang HZ,Wan KL,Li XW

更新日期：2015-02-01 00:00:00

abstract：:The emergence of multidrug-resistant (MDR) Gram-negative bacteria has become a major public health problem, eliciting renewed interest in colistin, an old antibiotic that is now routinely used to treat MDR bacterial infections. Here we investigated whether colistin use has affected the prevalence of infections due to ...

journal_title：International journal of antimicrobial agents

authors： Abat C,Desboves G,Olaitan AO,Chaudet H,Roattino N,Fournier PE,Colson P,Raoult D,Rolain JM

更新日期：2015-02-01 00:00:00

abstract：:The resistance patterns of Escherichia coli in untreated (raw) urban wastewater (UW) was monitored by repeated sampling during 1 year. Comparison with data from wastewater samples collected from hospital wastewater (HW) in the same urban area was made. A total of 1326 E. coli isolates from 17 UW samples and 451 isolat...

journal_title：International journal of antimicrobial agents

authors： Kwak YK,Colque P,Byfors S,Giske CG,Möllby R,Kühn I

更新日期：2015-01-01 00:00:00

abstract：:During a prospective surveillance using PCR for the detection of plasmid-mediated AmpC β-lactamase (pAmpC)-producing Enterobacteriaceae, outbreaks due to pAmpC-producing Klebsiella pneumoniae (pAmpC-Kp) occurred in an adult liver transplantation unit (aLTU) and a paediatric liver transplantation unit (pLTU), with carb...

journal_title：International journal of antimicrobial agents

authors： Matsumura Y,Tanaka M,Yamamoto M,Nagao M,Machida K,Ito Y,Takakura S,Ogawa K,Yoshizawa A,Fujimoto Y,Okamoto S,Uemoto S,Ichiyama S

更新日期：2015-01-01 00:00:00

abstract：:The objective of this study was to assess the comparative effectiveness and safety of antistaphylococcal penicillins (ASPs) and cephalosporins for the definitive treatment of patients with meticillin-susceptible Staphylococcus aureus (MSSA) bacteraemia. PubMed and Scopus electronic databases were searched up to Decemb...

journal_title：International journal of antimicrobial agents

authors： Vardakas KZ,Apiranthiti KN,Falagas ME

更新日期：2014-12-01 00:00:00

abstract：:Previous in vivo studies using a human-simulated regimen of ceftaroline/avibactam 600/600mg every 8h (q8h) showed activity against extended-spectrum β-lactamase-, AmpC- and KPC-producing Enterobacteriaceae with minimum inhibitory concentrations (MICs) ≤ 1 μg/mL. Here we sought to determine the efficacy of this human-s...

journal_title：International journal of antimicrobial agents

authors： Bhalodi AA,Crandon JL,Williams G,Nicolau DP

更新日期：2014-12-01 00:00:00

abstract：:The pharmacokinetic/pharmacodynamic (PK/PD) index for the efficacy of linezolid is a 24-h area under the plasma drug concentration-time curve (AUC₂₄)/minimum inhibitory concentration (MIC) ratio of ≥100. The main adverse event associated with administration of linezolid is thrombocytopenia. Therefore, the aims of the ...

journal_title：International journal of antimicrobial agents

authors： Matsumoto K,Shigemi A,Takeshita A,Watanabe E,Yokoyama Y,Ikawa K,Morikawa N,Takeda Y

更新日期：2014-09-01 00:00:00